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Wednesday, November 25, 2020 | History

2 edition of Bioassay of 3-nitropropionic acid for possible carcinogenicity. found in the catalog.

Bioassay of 3-nitropropionic acid for possible carcinogenicity.

National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Bioassay of 3-nitropropionic acid for possible carcinogenicity.

  • 190 Want to read
  • 39 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Propionic acid -- Toxicology.

  • Edition Notes

    SeriesDHEW publication -- no. (NIH) 78-1302, Carcinogenesis technical report series -- no. 52
    The Physical Object
    Paginationxi, 126 p. :
    Number of Pages126
    ID Numbers
    Open LibraryOL22412223M

      Sulphuric acid, con’t – exposure levels which do not cause irritation can be regarded to protect from carcinogenicity – e.g. in Finland OEL for sulphuric acid is mg/m3 / 8 h and 1 mg/m3 /15 min Formaldehyde – a weak genotoxic agent, but its local carcinogenic potential is considered to be mediated mainly via the mechanism involving. Dimethylarsinic acid (DMA V) administered at high doses in the diet or drinking water produces bladder tumors in rats, with females being more susceptible than contrast, tumors are not produced when even higher doses are administered to mice, and in short-term studies (10 weeks) there are no toxic or preneoplastic changes in the urinary tract of hamsters. Structure, properties, spectra, suppliers and links for: β-Nitropropionic acid, beta-Nitropropionic acid, Anthranilic acid is an aminobenzoic acid that is benzoic acid having a single amino substituent located at position 2. It is a metabolite produced in L-tryptophan - kynurenine pathway in the .


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Bioassay of 3-nitropropionic acid for possible carcinogenicity. by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

BIOASSAY OF 3-NITROPROPIONIC ACID FOR POSSIBLE CARCINOGENICITY. Carcinogenesis Testing Program Division of Cancer Cause and Prevention National Cancer Institute National Institutes of Health.

FOREWORD; This repor tht presente results osf th bioassae oyf 3-nitropropionic acid conducte for th Carcinogeneside s Testing. A bioassay of 3-nitropropionic acid (95% pure) for possible carcinogenicity was conducted by administering the test chemical by gavage to Fischer rats and B6C3F1 mice.

Groups of 50 rats and 50 mice of each sex were administered 3-nitropropionic acid at one of the following doses by gavage 5. Get this from a library. Bioassay of 3-nitropropionic acid for possible carcinogenicity. [National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention.]. Bioassay of 3-nitropropionic acid for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. OCLC Number. 3-Nitropropionic acid: Target Organs and Levels of Evidence for TR Bioassay of 3-Nitropropionic Acid for Possible Carcinogenicity (CASRN ) Chemical (Study Title).

Substances predicted as likely to meet criteria for category 1A or 1B carcinogenicity, mutagenicity, or reproductive toxicity. Pre-registered substances Substances indicated, Bioassay of 3-nitropropionic acid for possible carcinogenicity.

bookas being intended to be registered by at least one company in the EEA. 3-Nitropropionic acid is a toxic compound produced by several moulds involved in food fermentation or spoilage. An impure commercial sample of this compound was previously reported as being mutagenic to Salmonella typhimurium strains TA and TA In the present study, a sample from the same lot of 3-nitropropionic acid was mutagenic in strain TA without metabolic.

Long-Term Carcinogenicity. 2 years (Gavage) (C) Completed. TR (NIH Number: ) (Peer Review Approval 01/18/A) Bioassay of 3-Nitropropionic Acid for Possible Carcinogenicity (CASRN ) Rats: F/N; Mice: B6C3F1; Carcinogenesis Results.

Male Rats Equivocal ; Female Rats Negative ; Male Mice Negative. Based on the NOAEL of the chronic rodent bioassay, an ADI of 25 μg/kg/day or mg/day for a 70 kg human is appropriate.

3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate. Thus for of the chem- icals tested by the oral route in rats and mice, the mouse studies retrospectively can be considered superfluous, because they did not contribute to risk assessment decisions.

3 For nine chemicals (butyl benzyl phthalate, 3-nitropropionic acid, parathion, phosphamidon, picloram, TDE, heptachlor, toxaphene and. Molecules15 The 3-nitropropionic acid (3-NP) model Nowadays, researchers are able to study the post-mortem brains of HD patients and analyse biochemical-molecular parameters in biological media, such as blood and cerebrospinal fluid.

Myhr, B.C., and Caspary, W.J. Evaluation of the LY mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, I. heart preparation, ne rve conduction recording, 3-nitropropionic acid- induced ex perimental Hu ntington’s di sease in rats etc.

Mr Dhadde gained good citation index with H-Index of 09 and i beta-Nitropropionic acid (3-nitropropanoic acid, BPA, 3-NPA) is a mycotoxin, a potent mitochondrial inhibitor, toxic to humans. It is produced by Bioassay of 3-nitropropionic acid for possible carcinogenicity.

book number of fungi, and found widely in food, in sugar cane, as well as Japanese fungally fermented staples miso, soy sauce, katsuobushi, and some traditional Chinese medicines. It can be caused by extreme weather, stressed crop growth conditions, as.

Lau, M. Tymianski, in Comprehensive Toxicology, 3-Nitropropionic Acid. 3-Nitropropionic acid (3-NP) is a naturally occurring, abundant plant mycotoxin that is associated with neurologic illnesses in grazing animals and humans (Ludolph et al.

).Ingestion in livestock results in hindlimb weakness, knocking together of the hindlimbs while walking, and goose stepping. N - 3-Nitropropionic acid EMAIL THIS PAGE TO A FRIEND. To Email: From Email: Message: N Sigma-Aldrich 3-Nitropropionic acid ≥97% CAS Number Linear Formula O 2 N(CH 2) 2 CO 2 H.

Molecular Weight Beilstein/REAXYS Number EC Number 3-NITROPROPIONIC ACID is incompatible with bases, oxidizing agents and reducing agents.

(NTP, ) Belongs to the Following Reactive Group(s) Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

Footnotes ↵ 5 The abbreviations used are: 3-NP, 3-nitropropionic acid; OAA, oxaloacetatic acid; carboxin, 2-methyl-1,4-oxathiincarboxanilide; TTFA, thenoyl trifluoroacetone; SQR, succinate:quinone oxidoreductase; FRD, fumarate reductase; FCc, flavocytochrome c FRD; MS mass spectroscopy.

↵ 6 The predicted coordination distances were calculated as the sum of ionic radii, taking Å. SCH3 CAS TR 16() O CH, CI O C H il f I II 2 5 (CH50)z-P-O-C=C-C-N C,H, Azinphosmethyl Fenthion Phosphamidon Miscellaneous agents CAS TR 52() CAS TR () CAS TR 88() O,N-CHZCHZCOOH 3-Nitropropionic acid Dimethoxane O -C -CH, O 1,2,3-Benzotriazole a Additionally, these agents possess.

The morphologic and histochemical effects of 3‐nitropropionic acid (NPA) were examined in cultured murine embryonal carcinoma cells.

NPA caused a dose‐dependent inhibition of cell proliferation of cultured murine embryonal carcinoma cells at concentrations above mM and was lethal at mM. In vitro: 3-nitropropionic acid (3-NPA) is an irreversible inhibitor of complex II in the mitochondria.

It impairs cellular energy metabolism via inhibition of succinate dehydrogenase, which induces a reduction in ATP production and leads to oxidative stress. 3-NPA can cause the generation and release of ROS from mitochondria, mitochondrial DNA damage, and thus loss of mitochondrial function.

Abstract. For many years prior to its recent discovery and exploitation as a chemical tool for investigation of various neurodegenerative disorders in humans, 3-nitropropionic acid (3-NPA) intoxication following ingestion of plants has been a substantial problem in domestic livestock.

Again, a dose-response effect was evident for the positive compounds. 5 of the positive chemicals were reported as carcinogenic in the in vivo bioassay (Table 4) while p-chloroaniline was judged suspect and 3-nitropropionic acid was associated with an indication of carcinogenicity.

5 of the 8 negative compounds were noncarcinogens and of the 3. The topics covered include an introduction to multistage carcinogenesis and an overview of genotoxic and nongenotoxic carcinogen action. acid histidine. carcinogenicity assessment.

For. Sigma-Aldrich offers a number of 3-Nitropropionic acid products. View information & documentation regarding 3-Nitropropionic acid, including CAS, MSDS & more. A bioassay of p,p'-ethyl-DDD for possible carcinogenicity was conducted by administering the test chemical in feed to F rats and B6C3F1 mice.

Groups of 50 rats of each sex were administered p,p'-ethyl-DDD at one of two doses, either 3, or 7, ppm, for weeks. Matched controls consisted of. Huang et al () 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in.

Interestingly, 3-nitropropionic acid (3-NP), a potent neurotoxin that interferes with mitochondrial respiration induced segmental or generalized dystonia in patients [19,20]. Administration of 3-NP in rodents resulted in selective striatal lesions [ 18, 21, 22 ] and was associated with delayed onset dystonia, which is characterized by.

However, anatomo-pathological studies and behavioural studies in animal models using mitochondrial toxins support this hypothesis. Of all of the substances used for this purpose, 3-nitropropionic acid (3NP) is the most commonly used, and it shares many mechanisms of. Abstract. 3-Nitropropionic acid (3-NA) was originally identified as a component of moldy sugarcane, produced by a fungus, Arthrinium sp.

Ingestion of the mildewed sugarcane results in motor impairment and muscle weakness that is neither progressive nor reversible, and is accompanied by bilateral damage to the striatum (1,2) (see also Chapters 1, 2, 5, 10, and 12).

3-Nitropropionic acid is a plant and fungal toxin, 3-nitropropionic acid acts as an irreversible inactivator of succinate dehydrogenase.

Selectively inhibits succinic dehydrogenase complex (Complex II) in the mitochondrial electron transport chain. Also s. Bioassay of anthranilic acid for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. OCLC Number: Notes: Spine title: Anthranilic acid. "CAS no. The production of β- nitropropionic acid by a strain of Aspergillus flavus.

Bush, Milton T.; Touster, Oscar; Brockman, Jean Early Journal of Biological Chemistry (),An antibiotic substance, oryzacidin, produced by Aspergillus oryzae. Existence of β- nitropropionic acid. Goodman G, Wilson R. Predicting the carcinogenicity of chemicals in humans from rodent bioassay data.

Environ Health Perspect. Aug; – [PMC free article] Tomatis L, Aitio A, Wilbourn J, Shuker L. Human carcinogens so far identified.

Jpn J Cancer Res. Sep; 80 (9)– 6 bioassay of anthranilic acid for possible carcinogenicity cas no. nci-cg-tr of health bioassay of anthranilic acid for possible carcinogenicity TR Lithocholic Acid (CASRN. Exposure of cultures to 3 mM 3-nitropropionic acid for 3 h did not cause overt toxicity, but reduced ATP content by 35%.

Treatment with 3-nitropropionic, or removal of Mg2+ from the medium, enhanced subsequent N-methyl-D-aspartate toxicity, reducing the LC50 from microM to 12 microM or 30 microM, respectively.

Bioassay of 4-nitroanthranilic acid for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. OCLC Number: Notes: "CAS no.

" Description. Bioassay of 4-nitroanthranilic acid for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. A bioassay of 4-nitroanthranilic acid for possible carcinogeni­ city was conducted using Fische 34r4 rats and B6C3F1 mice. 4-Nitro­ anthranilic acid wa s administere idn th feede, at either of two concentrations, to groups of 50 male and 5 femal0 e animal osf each species.

Th higeh and lo time-weightew d average concentrations used. The lipid research clinics population studies data book by National Heart, Lung, and Blood Institute.

texts. eye Bioassay of 4-aminonitrophenol for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention Bioassay of 3-nitropropionic acid for possible carcinogenicity by. Ludolph AC, He F, Spencer PS, Hammerstad J, Sabri M. 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin.

Can J Neurol Sci. ; – [ PubMed ].Avantor ®, a Fortune company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve.3-Nitropropionic Acid - Investigated as a drug, mutagen, primary irritant, and tumorigen.

Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. See actual entry in RTECS for complete information. 3-Nitropropionic Acid RTECS Number: UF